In aqueous systems bromhexine hydrochloride br hcl has a poor solubility 4. Material safety data sheet of bromhexine hcl abmole. Extreme high moderate low section 1 chemical product and company identification product name bromhexine hydrochloride statement of hazardous nature considered a hazardous substance according to osha 29 cfr 1910. Validated rphplc method for determining the levels of. Bromhexine hydrochloride is a mucolytic agent that exerts both a secretagogic action on submucosal glands and a mucolytic action toward acid glycoproteins inside cells. Lgm pharma offers this active ingredient but not the finished dosage forms. Other companies are charging thousands of dollars to set up accounts and give you access to their msds. Animal studies have shown adverse effects of bromhexine inhaler, syrup and tablets on the unborn baby. Bromhexine hcl 4 mg5 ml oral solution bromhexine hcl 8. Download msds material safety data sheet of enrofloxacin. This increased lysosomal activity enhances hydrolysis of acid mucopolysaccharide polymers, which significantly contribute to normal mucus viscosity. Bromhexine is a cough suppressant used to relieve productive cough with phlegm. Know bromhexine 8mg tablet uses, sideeffects, composition, substitutes, drug interactions, precautions, dosage, warnings only on. It increases production of serous mucus, decrease mucus viscosity and helps cilia transport mucus out of the lungs.
Proposed medicines must comply with all aspects of the monograph relevant to their strength and dosage form to qualify for evaluation as an n2 application. Some health conditions may make you more susceptible to the sideeffects of the drug. Bromhexine decreases mucus viscosity by increasing lysosomal activity. Bromhexine hcl suppliers, manufacturer, distributor. Therefore the drug is molecularly dispersed in water until the solubility product of br hcl is exceeded. Cb839telaglenastat new cb839 is a potent, selective, and orally bioavailable glutaminase inhibitor with ic50 of 24 nm for recombinant human gac. Bromhexine hcl tablet works by increasing the viscid or excessive mucus in respiratory tract thus making phlegm thinner. Composition and information on ingredients composition. For research use only, not for human or veterinary use. The authorised indications of bromhexine, as listed in the company core data sheet of.
Bromhexine hcl is a synthetic vasicine derivative used to treat mucusrelated respiratory disorders. There are 38 suppliers who sells bromhexine hcl bp on, mainly located in asia. Bromhexine is used for common cold symptoms, influenza flu, respiratory tract infection etc. This document has been prepared in accordance with standards for workplace safety, which require the inclusion of all known hazards of the active substance or its intermediates regardless of the potential risk. Bromhexine is clinically used to treat respiratory disorders characterized by excessive mucus. Bromhexine causes phlegm to become thinner by its secretolytic action, contributing to its expulsion. Before using bromhexine hydrochloride, inform your doctor about your current list of medications, over the counter products e. Bromhexine hydrochloride sc204656 hazard alert code key. Bromhexine is contained in various formulations, high and low strength syrups 8 mg5 ml, 4 mg5 ml, tablets and soluble tablets both with 8 mg bromhexine and solution for oral use 10 mg5 ml, adapted to the need of the patients. The ph was adjusted using a glycine hcl buffer solution this buffer was chosen on account of its elevated complexing ability, which could be of use in overcoming interferences. It is an expectorant and a mucolytic agent that melts sticky and hard phlegm, which helps clear mucus from the respiratory tract. Proposed medicines must comply with all aspects of the monograph relevant to their strength and dosage form. Other drugs that have the same active ingredients e. As a mucolytic, it helps to relieve productive cough by thinning the phlegm in the airways and facilitating the removal of the mucus.
Asked in geology, medication and drugs, blood types, firefighters. Presentation the active ingredient in bromhexine is bromhexine hydrochloride. Find high quality bromhexine hcl suppliers on alibaba. A comparative trial of bromhexine hcl and oxytetracycline in acute and. Solubilization of bromhexine hydrochloride in aqueous.
Information for bromhexine hcl 611756 including bromhexine hcl cas no 611756, bromhexine hcl suppliers, bromhexine hcl manufacturers, related products of bromhexine hcl. Inquire about dmf, cgmp, price, availability, samples, sourcing, purity and more. Bromhexine increases production of serous mucus, decreases mucus viscosity, and helps cilia transport mucus out of the lungs. Chemical product and company identification product name.
Ambroxol is a metabolite of bromhexine distribution it is widely distributed to body tissues bromhexine is highly bound to plasma proteins bromhexine crosses the bloodbrain barrier and small amounts cross the placenta. The product is intended for research, analysis and scientific education. This calculation results in a rat equivalent dose for resveratrol of 11. The study is based on warfarin sodium and bromhexine hydrochloride the active ingredients of warfarin sodium and bromhexine hydrochloride, respectively, and warfarin sodium and bromhexine hydrochloride the brand names. Bromhexine hydrochloride cas 611756 scbt santa cruz. Know bromhexine uses, sideeffects, composition, substitutes, drug interactions, precautions, dosage, warnings only on.
This tends to be given to those with respiratory diseases who have difficulty coughing this out otherwise by breaking it down it becomes smaller and easier to expel and this means they can breathe without their airways being blocked while also providing cough relief. It is a drug with mucolytic action, which is generally used in the treatment of respiratory problems associated with the presence of a viscous or excessive mucus. Bromhexine hcl brom, chemically named 2amino3, 5dibromoncyclohexylnmethyl benzenemethanamine hydrochloride, is a mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. Formulation and stability evaluation of 1% wv oral. Labchem inc jacksons pointe commerce park building, 1010 jacksons pointe court 16063 zelienople, pa usa t 4128265230 f 7244730647. Assay of bromhexine hydrochloride in pharmaceutical.
Combinations of decongestant and antihistamine preparations are widely used for cough and cold treatments. This monograph only applies to preparations that contain bromhexine hydrochloride cas no. Bromhexine 8mg tablet is used for asthma, chronic obstructive pulmonary disorder copd etc. Sigmaaldrich offers a number of bromhexine hydrochloride products. Bromhexine hcl 611756, information for bromhexine hcl 611. Each tablet of bisolvon chesty forte contains bromhexine hydrochloride 8 mg. A list of us medications equivalent to bromhexine hydrochloride 0.
Formulation and stability evaluation of 1% wv oral solution. Alibaba offers 420 bromhexine hcl suppliers, and bromhexine hcl manufacturers, distributors, factories, companies. Bromhexine should be used during pregnancy only if the benefit to the mother outweighs the risk to the fetus. Bromhexine is a substituted aniline that is 2,4dibromoaniline which is substituted at position 6 by a cyclohexylmethylaminomethyl group. Bromhexine 8mg tablets mucolytic agent for coughs order. Find patient medical information for bromhexine hcl bulk on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Bromhexine tablet bromhexine is used in a condition where there is a lot of thick phlegm in the airways. It should not be used during the first three months of pregnancy unless recommended by doctor. Setanaxib gkt7831 new gkt7831 is a potent, dual nadph oxidase nox1nox4 inhibitor with ki of 110 nm and 140 nm, respectivelyl. Toluenealpha, 2diamine, 3,5dibromonsup alphacyclohexylnsup alphamethyl. Bromhexine hydrochloride is a medication prescribed for coughs which works by dissolving hard phlegm. Bromhexine 8mg tablet uses, side effects, substitutes. The posology varies with the age and weight, but there are products for all age groups from infant on.
Bromhexine uses, side effects, substitutes, composition. Bromhexine hydrochloride manufacturer of bromhexine hcl. Bromhexine hcl 8 mg5 ml oral solution based on maltitol syrup without sorbitol active ingredient bromhexine hydrochloride strength 4 mg5 ml 8 mg5 ml therapeutic indication common cold, influenza, infections of the respiratory tract or in other conditions associated with abnormal mucus. Bromhexine hcl tablet contains bromhexine as an active ingredient. It is intended to support the bodys mechanisms for clearing mucus from the respiratory tract it is secretolytic, increases the production of serous mucus in the respiratory tract and makes the phlegm thinner and less viscous.
Sds of bromhexine hydrochloride, safety data sheets, cas 611756. View indentification, hazards, safety information, toxicity, regulations. Bromhexine hydrochloride is a hydrochloride resulting from the reaction of equimolar amounts of bromhexine and hydrogen chloride. Bromhexine is a synthetic derivative of vasicine that exhibits mucolytic and antioxidative activities. It is used as the monohydrochloride salt as a mucolytic for the treatment of respiratory disorders associated with productive cough i. Bromhexine hydrochloride, antioxidant agent ab143585. Bromhexine hydrochloride is a synthetic derivative of the alkaloid vasicine. Bromhexine hcl is a medication prescribed for coughs which works by dissolving hard phlegm.
Excretion bromhexine is excreted primarily in the urine as metabolites. For example, to modify the dose of resveratrol used for a mouse 22. This tends to be given to those with respiratory diseases who have difficulty coughing this out otherwise by breaking it down it becomes smaller and easier to expel and this means they can breathe without their airways being blocked while. Before using bromhexine hcl tablet, inform your doctor about your current list of medications, over the counter products e.
Safety data sheet according to 29cfr19101200 and ghs rev. Bromhexine hcl 4 mg5 ml oral solution bromhexine hcl 8 mg5 ml oral solution based on maltitol syrup without sorbitol active ingredient bromhexine hydrochloride strength 4 mg5 ml 8 mg5 ml therapeutic indication common cold, influenza, infections of the respiratory tract or in other conditions. Relevant identified uses of the substance or mixture and uses advised against 1. Your new online msds binder is a place for you to store the material safety data sheets you need to deploy. Ambroxol and bromhexine containing medicinal products. Material safety data sheet bromhexine hydrochloride msds section 1. Hydrochloride overdose should be symptomatic and supportive. Material safety data sheet bromhexine hydrochloride sc204656 hazard alert code key. It is used as a mucolytic for the treatment of respiratory disorders associated with productive cough i. Material safety data sheet boehringer ingelheim vetmedica. Bromhexine hydrochloride c14h21br2cln2 cid 5702220 structure, chemical names, physical and chemical properties, classification, patents, literature. Formulation and stability evaluation of 1% wv oral 16 2. Acceptable dosage forms and strengths are shown in the table below.
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